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Sengenics: revolucionando a descoberta de biomarcadores de autoanticorpos
A Sengenics é uma empresa líder em biotecnologia especializada no desenvolvimento de tecnologias serômicas pioneiras no setor. Os recursos exclusivos da empresa revolucionaram a descoberta de biomarcadores de autoanticorpos clinicamente relevantes, essenciais para o diagnóstico e tratamento de várias doenças.
Com sede em Cingapura, a Sengenics se estabeleceu como líder global no campo da serômica. As tecnologias de ponta da empresa têm sido usadas por pesquisadores e médicos em todo o mundo para identificar novos biomarcadores para doenças autoimunes, câncer, doenças infecciosas e outras condições.
O que diferencia a Sengenics de outras empresas de biotecnologia é seu foco em matrizes de proteínas. Ao contrário dos métodos tradicionais que dependem do sequenciamento de DNA ou RNA para identificar biomarcadores, o Sengenics usa matrizes de proteínas para detectar autoanticorpos diretamente. Esta abordagem oferece várias vantagens sobre os métodos convencionais.
Em primeiro lugar, as matrizes de proteínas permitem a triagem de alto rendimento de milhares de proteínas simultaneamente. Isso significa que os pesquisadores podem identificar rapidamente potenciais biomarcadores sem precisar testar cada um individualmente. Em segundo lugar, os arrays de proteínas são altamente sensíveis e específicos, o que significa que podem detectar até níveis baixos de autoanticorpos com alta precisão.
A principal tecnologia da Sengenics é chamada KREX (Killer-REx), que significa "Killer-Exonuclease". KREX é uma plataforma patenteada que permite a produção de proteínas recombinantes completas com conformações nativas. Esta tecnologia permite aos pesquisadores rastrear um grande número de proteínas de uma só vez, mantendo sua estrutura e função naturais.
Outra tecnologia chave desenvolvida pela Sengenics é chamada ImmuSAFE (Immunoglobulin Signature Assessment by Fluorescence Emission). O ImmuSAFE é um método proprietário para detectar autoanticorpos usando antígenos marcados com fluorescência. Essa técnica permite que os pesquisadores visualizem os padrões de ligação entre anticorpos e antígenos em tempo real.
As tecnologias da Sengenics foram usadas em vários estudos de pesquisa e ensaios clínicos. Por exemplo, a empresa colaborou com pesquisadores da Universidade de Oxford para identificar biomarcadores de autoanticorpos para esclerose múltipla (EM). O estudo, publicado na Nature Communications, identificou vários novos biomarcadores que podem ser usados para diagnosticar e monitorar a EM.
A Sengenics também fez parceria com várias empresas farmacêuticas para desenvolver novos medicamentos com base em suas tecnologias serômicas. Em 2019, a empresa anunciou uma colaboração com a Takeda Pharmaceutical Company Limited para descobrir e validar biomarcadores de autoanticorpos para doença inflamatória intestinal (DII).
Além de suas colaborações de pesquisa, a Sengenics oferece uma variedade de serviços para apoiar a descoberta e o desenvolvimento de medicamentos. Esses serviços incluem expressão e purificação de proteínas, produção de anticorpos, desenvolvimento de ensaios e análises de bioinformática.
No geral, a Sengenics é uma empresa pioneira de biotecnologia que transformou o campo da serômica. Suas tecnologias inovadoras permitiram que pesquisadores de todo o mundo acelerassem a descoberta de biomarcadores de autoanticorpos clinicamente relevantes para várias doenças. Com seu foco contínuo em inovação e colaboração, a Sengenics está pronta para fazer contribuições ainda maiores nos próximos anos.
sengenics.com
