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Eligo Bioscience: Revolucionando a Saúde com Tecnologias de Edição de Genes In Vivo
A Eligo Bioscience é uma empresa de biotecnologia dedicada a revolucionar a saúde, implantando tecnologias de edição de genes in vivo contra alvos de microbioma. A missão da empresa é atender doenças com altas necessidades não atendidas, e tem dado passos significativos nesse sentido.
O microbioma refere-se à coleção de microorganismos que vivem dentro e dentro de nossos corpos. Esses microrganismos desempenham um papel crucial na manutenção da nossa saúde, mas quando ficam desequilibrados ou interrompidos, podem levar a uma série de doenças. A abordagem da Eligo Bioscience envolve o uso de tecnologias de edição de genes para direcionar seletivamente e modificar bactérias específicas dentro do microbioma.
Uma das principais vantagens dessa abordagem é sua precisão. Ao contrário dos antibióticos tradicionais, que podem matar bactérias prejudiciais e benéficas indiscriminadamente, a tecnologia da Eligo Bioscience permite intervenções direcionadas que afetam apenas cepas específicas de bactérias. Isso significa que os pacientes podem receber tratamento sem interromper o equilíbrio geral do microbioma.
A Eligo Bioscience desenvolveu uma plataforma proprietária chamada "Bacteriófagos habilitados para CRISPR" (crPhage) que combina a tecnologia CRISPR-Cas com bacteriófagos - vírus que infectam bactérias - para fornecer cargas úteis de edição de genes direcionadas diretamente às células bacterianas. Esta plataforma mostrou resultados promissores em estudos pré-clínicos para uma série de indicações, incluindo infecções do trato urinário (ITUs), doença inflamatória intestinal (DII) e câncer colorretal.
Além de sua plataforma crPhage, a Eligo Bioscience também está desenvolvendo outras abordagens inovadoras para atingir o microbioma. Por exemplo, a empresa desenvolveu "cápsulas inteligentes" - dispositivos ingeríveis contendo bactérias modificadas - que podem detectar e responder a mudanças no ambiente intestinal.
A Eligo Bioscience foi fundada em 2014 pelos Drs. Xavier Duportet e David Bikard no Institut Pasteur em Paris. Desde então, a empresa levantou mais de US$ 40 milhões em financiamento de investidores como Khosla Ventures, Seventure Partners e Illumina Ventures. A empresa também estabeleceu parcerias com empresas farmacêuticas líderes, como GSK e AbbVie, para desenvolver sua tecnologia para indicações específicas.
A abordagem inovadora da Eligo Bioscience para a edição genética direcionada ao microbioma tem o potencial de transformar a saúde, fornecendo tratamentos mais precisos e eficazes para uma variedade de doenças. Com sua tecnologia de ponta e fortes parcerias, a empresa está bem posicionada para liderar esse campo emergente e causar um impacto significativo na vida dos pacientes.
eligo-bioscience.com
